CDithem

Consortium for Discovery and Innovation in Therapy and Medicine

  CDithem provides services to discover small molecular modulators of PPI targets with a drug discovery or chemical biology perspective.

Thus, CDithem can help you to:

  • Optimize the purification process of the proteins of interest

  • Develop target-tailored screening assays based on Fluorescence Polarization (FP), ELISA, Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Differential Scanning Calorimetry (DSC) and cell-based assays (eg Bioluminescence Resonance Energy Transfer (BRET))

  • Prepare target-specific chemical libraries for screening and optimization using proprietary chemoinformatics technologies

  • Identify hits and chemical probes using virtual and experimental screening techniques

  • Optimize selected compounds toward a proof of concept in an animal model by combining experimental and computer-aided protocols